Report on PRA - Maureen Sharp January
have just heard from the AHT who sent me the following.
have heard that we have been awarded large scale
funding to look at PRA and HC in various breeds
of dog - which is good news for the Tibetan Spaniel
as we listed it among the first 4 breeds we will
work on. We have already looked at a small number
(23) candidate genes, but unfortunately none turned
out to be involved with PRA in the TS.
We have already examined about 400 genetic markers
from all over the canine genome, trying to identify
regions that appear linked (or close to) the gene
that is causing PRA in your breed. That is in addition
to the 23 candidate genes we have analysed. So we
have tried hard to find your mutation! Sometimes
it is the luck of the draw and I'm sorry to say
we have not been lucky so far with this disease.
In contrast, we looked at a similar number of candidate
genes in our search for the gene that causes HC
in another breed and got lucky - that breed now
has a DNA test. So we have been using sensible strategies,
we have just been unlucky. But our new project,
which is being funded to the tune of £250,000
is an exciting one, and we hope it will turn our
So, please be patient with us for a bit longer -
we are trying everything we know to find your mutation."
Sharp (Co-ordinator - PRA Fund)